The legendary drug trafficker Alono Marroquín, who, with his son Lucas escapes from a high-security Mexican prison and finds refuge in Paradiso, a remote drug rehabilitation facility located in The American side of the border. Meanwhile, the bodies of wounded soldiers who were victims of a failed military experiment by the U.S., are abandoned near the border, and then revived as mutant zombies. In the search for Alonso and his son, the Mexican special forces team is infected by mutant zombies, becoming a zombie army. Alerted by the imminent threat that this new species represents for humanity, the United States Army embarks on a mission to annihilate them.