Sekar is an IT employee who does not like his job much. His neighbor Rajarajan is a scientist who is hellbent on proving that it is possible to alter the DNA of humans and animals, thereby making humans have characteristics of animals.
While the result of his experiment goes unexpected, one day a dog named Padayappa bites Sekar and that ends up in their characteristics getting swapped. What happens next and how they get back to their original selves forms the rest of the plot.
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